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What (who) is repair program - definition

DNA REPAIR MECHANISM

Transcription-coupled repair; Transcription-Coupled Repair; Transcription coupled repair; Nucleotide excition repair; Transcription-coupled nucleotide excision repair

DNA repair

PROCESS OF RESTORING DNA AFTER DAMAGE

Dna repair; DNA Repair; DNA damage; DNA repair genes; Excision repair; Excision repair mechanism; Dna repair enzymes; Dna repair-deficiency disorders; Dna repair genes; Double-strand breaks; Double-strand break; Types of DNA lesions; Double strand breaks; Translesion synthesis; DNA damage checkpoint; Double strand break; Self-repair mechanisms; DNA repair gene; Single strand break; Single-strand break; DNA damage checkpoints; DNA lesions; DNA lesion; Translesion; Translation polymerase; DNA-damage response; DNA repair-deficiency disorders; Translesion DNA synthesis; Double-stranded break; Single-stranded break; DNA damage repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day.

https://en.wikipedia.org/wiki/DNA_repair

Nucleotide excision repair

Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.

https://en.wikipedia.org/wiki/Nucleotide_excision_repair

Computer program

SEQUENCE OF INSTRUCTIONS WRITTEN IN PROGRAMMING LANGUAGE TO PERFORM A SPECIFIED TASK WITH A COMPUTER

Computer programme; Computer code; Computer programs; Software program; Program (programming); Program (computer science); Program (computing); Computer Program; Software code; Program (computer); Computer Programs; Program file; Computer program code; Program module

A computer program is a sequence or set of instructions in a programming language for a computer to execute. Computer programs are one component of software, which also includes documentation and other intangible components.

https://en.wikipedia.org/wiki/Computer_program

Wikipedia

Nucleotide excision repair

Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs.

Nucleotide excision repair (NER) is a particularly important excision mechanism that removes DNA damage induced by ultraviolet light (UV). UV DNA damage results in bulky DNA adducts - these adducts are mostly thymine dimers and 6,4-photoproducts. Recognition of the damage leads to removal of a short single-stranded DNA segment that contains the lesion. The undamaged single-stranded DNA remains and DNA polymerase uses it as a template to synthesize a short complementary sequence. Final ligation to complete NER and form a double stranded DNA is carried out by DNA ligase. NER can be divided into two subpathways: global genomic NER (GG-NER or GGR) and transcription coupled NER (TC-NER or TCR). The two subpathways differ in how they recognize DNA damage but they share the same process for lesion incision, repair, and ligation.

The importance of NER is evidenced by the severe human diseases that result from in-born genetic mutations of NER proteins. Xeroderma pigmentosum and Cockayne's syndrome are two examples of NER associated diseases.

https://en.wikipedia.org/wiki/Nucleotide excision repair

Examples of use of repair program

1. Lewis maintained that the leak–repair program is "effective," and he said it should be viewed separately from new evidence indicating water continues to leak steadily into O‘Neill tunnel.

2. To help solidify support among the people who live in this rundown neighbourhood, the project operates an emergency repair program to help locals fix up their own homes that share the decrepit state of the historic buildings.

3. Jim Douglas recently announced a $3 million repair program dubbed "Operation Smooth Ride." In Massachusetts, problems started showing up earlier than usual, said state Highway Department spokesman Adam Hurtubise.

4. "It‘s enjoyable to be over here." "Working with soldiers, they are just so grateful," said Tracy Kammer of Davenport, Iowa, who came to Iraq as a federal intern in the small arms repair program.

5. That meant the company was often paid twice to fix equipment it didn‘t repair correctly the first time. Although it sounds bad economically, back at the time we were trying to (implement) a repair program that would maintain equipment for our soldiers, and that was a good alternative,‘‘ Hobby said of the ITT contract. It was expensive.